XL IGH / MAF
100 µl / 10 Tests
The XL IGH/MAF is designed as a dual fusion probe. Sets of orange labeled probes flank the breakpoint at 16q23 (MAF), while a set of green labeled probes flank the breakpoint at 14q32 (IGH).
The t(14;16)(q32;q23) occurs in 5% of multiple myeloma patients and has a clear association with an adverse outcome, with shorter survival and features of aggressiveness. While C-MAF up-regulation is believed to be a culprit, WWOX is also disrupted by breakpoints at 16q23 which indicates a possible tumor suppressor role for this gene. All MetaSystems Human FISH probe products are classified as IVD products and marked with the CE label.
Please use the following links to download additional information on this probe kit:
D-5029-100-OG: Package Insert (English): INS-D-5029-100-OG-EN (PDF file)
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Chesi et al (1998) Blood 91:4457-4463
Chesi et al (2000) Ann Onco 11:131-135
Fonseca et al (2003) Blood 101:4569-4575
Probe Kit Photo (click to enlarge): XL IGH/MAF was hybridized to normal lymphocytes. Metaphase and interphase are displayed.
Probe Kit Map (click to enlarge)
Expected Signal Patterns (only most common patterns are shown):
|Normal Cell: Two green (2G) and two orange (2O) signals.||Aberrant Cell (typical results): One green (1G), one orange (1O), and two green-orange fusion (2GO) (adjacent green and orange) signals.|