MetaSystems International Website| Select by Chromosome: |                           |
Product | Label | Order No. | Pack Size |
XL IGH / MAF | D-5029-100-OG | 100 µl / 10 Tests |
The XL IGH/MAF is designed as a dual fusion probe. Sets of orange labeled probes flank the breakpoint at 16q23 (MAF), while a set of green labeled probes flank the breakpoint at 14q32 (IGH).
Legal notice: For this probe kit additional information is available, which is only valid outside the United States of America (USA). You may open this information by clicking the button below. With this action you confirm that you have read this legal notice, that you agree with the terms of use, and that you are not intending to use the information within USA.
Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.
The t(14;16)(q32;q23) occurs in 5% of multiple myeloma patients and has a clear association with an adverse outcome, with shorter survival and features of aggressiveness. While C-MAF up-regulation is believed to be a culprit, WWOX is also disrupted by breakpoints at 16q23 which indicates a possible tumor suppressor role for this gene. All MetaSystems Human FISH probe products are classified as IVD products and marked with the CE label.
Please use the following links to download additional information on this probe kit:
D-5029-100-OG: Package Insert (English): INS-D-5029-100-OG-EN (PDF file)
Legal notice:The content above partly shows information which is not valid inside the United States of America (USA). If you would like to hide this part of the information please use the button below.
The t(14;16)(q32;q23) occurs in 5% of multiple myeloma patients and has a clear association with an adverse outcome, with shorter survival and features of aggressiveness. While C-MAF up-regulation is believed to be a culprit, WWOX is also disrupted by breakpoints at 16q23 which indicates a possible tumor suppressor role for this gene. All MetaSystems Human FISH probe products are classified as IVD products and marked with the CE label.
Please use the following links to download additional information on this probe kit:
D-5029-100-OG: Package Insert (English): INS-D-5029-100-OG-EN (PDF file)
Legal notice:The content above partly shows information which is not valid inside the United States of America (USA). If you would like to hide this part of the information please use the button below.
Literature:
Chesi et al (1998) Blood 91:4457-4463
Chesi et al (2000) Ann Onco 11:131-135
Fonseca et al (2003) Blood 101:4569-4575
Images:
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Probe Kit Photo (click to enlarge): XL IGH/MAF was hybridized to normal lymphocytes. Metaphase and interphase are displayed. | Probe Kit Map (click to enlarge) |
Expected Signal Patterns (only most common patterns are shown):
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| Normal Cell: Two green (2G) and two orange (2O) signals. | Aberrant Cell (typical results): One green (1G), one orange (1O), and two green-orange fusion (2GO) (adjacent green and orange) signals. |
For product and price inquiries, please contact our distribution partner in your country (see here). Mail to probes@metasystems.de to contact the MetaSystems DNA probe department directly. Please specify the ordering number as given above in any of your inquiries to allow for fast execution. All MetaSystems probe kits have a shelf life of 12 month (guaranteed). Due to their excellent stability they are shipped at room temperature. Download the latest MetaSystems DNA probe kit catalogue from here.
 | Single Probekit Page: XL IGH / MAF | Last updated: 07 March 2013 |