XL PML / RARA
100 µl / 10 Tests
The XL PML/RARA probe is designed as a dual fusion probe. An orange labeled probe spans the breakpoint at 15q24 (PML) and a green labeled probe the breakpoint at 17q21 (RARA).
AML M3 and AMLM3v are characterized by a reciprocal translocation between the long arm of chromosome 15 and the long arm of chromosome 17. This translocation leads to a rearrangement of the PML-gene situated on chromosomal band 15q24 and the RARA-gene situated on band 17q21. The PML-RARA-rearrangement has gained major clinical importance as combining all transretinoic acid (ATRA) and conventional anthracy-cline-cytarabin based chemotherapy has improved the prognosis in this subgroup of AML dramatically. All MetaSystems Human FISH probe products are classified as IVD products and marked with the CE label.
Please use the following links to download additional information on this probe kit:
D-5023-100-OG: Package Insert (English): INS-D-5023-100-OG-EN (PDF file)
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Lafage-Pochitaloff et al (1995) Blood 85:1169-1174
Grimwade et al (2000) Blood 96:1297-1308
Schoch et al (2002) Hematol-J 3: 259-263
Probe Kit Photo (click to enlarge): XL PML/RARA was hybridized to lymphocytes. Two normal interphase cells are displayed.
Probe Kit Map (click to enlarge)
Expected Signal Patterns (only most common patterns are shown):
|Normal Cell: Two green (2G) and two orange (2O) signals.||Aberrant Cell (typical results): One green (1G), one orange (1O), and two green-orange fusion (2GO) (adjacent green and orange) signals.|