MetaSystems International Website| Select by Chromosome: |                           |
Product | Label | Order No. | Pack Size |
XL PML / RARA | D-5023-100-OG | 100 µl / 10 Tests |
The XL PML/RARA probe is designed as a dual fusion probe. An orange labeled probe spans the breakpoint at 15q24 (PML) and a green labeled probe the breakpoint at 17q21 (RARA).
Legal notice: For this probe kit additional information is available, which is only valid outside the United States of America (USA). You may open this information by clicking the button below. With this action you confirm that you have read this legal notice, that you agree with the terms of use, and that you are not intending to use the information within USA.
Seven recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category AML with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.
AML M3 and AMLM3v are characterized by a reciprocal translocation between the long arm of chromosome 15 and the long arm of chromosome 17. This translocation leads to a rearrangement of the PML-gene situated on chromosomal band 15q24 and the RARA-gene situated on band 17q21. The PML-RARA-rearrangement has gained major clinical importance as combining all transretinoic acid (ATRA) and conventional anthracy-cline-cytarabin based chemotherapy has improved the prognosis in this subgroup of AML dramatically. All MetaSystems Human FISH probe products are classified as IVD products and marked with the CE label.
Please use the following links to download additional information on this probe kit:
D-5023-100-OG: Package Insert (English): INS-D-5023-100-OG-EN (PDF file)
Legal notice:The content above partly shows information which is not valid inside the United States of America (USA). If you would like to hide this part of the information please use the button below.
AML M3 and AMLM3v are characterized by a reciprocal translocation between the long arm of chromosome 15 and the long arm of chromosome 17. This translocation leads to a rearrangement of the PML-gene situated on chromosomal band 15q24 and the RARA-gene situated on band 17q21. The PML-RARA-rearrangement has gained major clinical importance as combining all transretinoic acid (ATRA) and conventional anthracy-cline-cytarabin based chemotherapy has improved the prognosis in this subgroup of AML dramatically. All MetaSystems Human FISH probe products are classified as IVD products and marked with the CE label.
Please use the following links to download additional information on this probe kit:
D-5023-100-OG: Package Insert (English): INS-D-5023-100-OG-EN (PDF file)
Legal notice:The content above partly shows information which is not valid inside the United States of America (USA). If you would like to hide this part of the information please use the button below.
Literature:
Lafage-Pochitaloff et al (1995) Blood 85:1169-1174
Grimwade et al (2000) Blood 96:1297-1308
Schoch et al (2002) Hematol-J 3: 259-263
Images:
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Probe Kit Photo (click to enlarge): XL PML/RARA was hybridized to lymphocytes. Two normal interphase cells are displayed. | Probe Kit Map (click to enlarge) |
Expected Signal Patterns (only most common patterns are shown):
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| Normal Cell: Two green (2G) and two orange (2O) signals. | Aberrant Cell (typical results): One green (1G), one orange (1O), and two green-orange fusion (2GO) (adjacent green and orange) signals. |
For product and price inquiries, please contact our distribution partner in your country (see here). Mail to probes@metasystems.de to contact the MetaSystems DNA probe department directly. Please specify the ordering number as given above in any of your inquiries to allow for fast execution. All MetaSystems probe kits have a shelf life of 12 month (guaranteed). Due to their excellent stability they are shipped at room temperature. Download the latest MetaSystems DNA probe kit catalogue from here.
 | Single Probekit Page: XL PML / RARA | Last updated: 07 March 2013 |