@article{May2008, author = "Philippa C May and Caroline Mackie Ogilvie and Shehla Mohammed and Zoe Docherty and Richard Peter Hall", abstract = "Karyotyping is currently the "gold standard" test for the detection of human chromosome abnormalities. Over the past 40 years, changes in techniques have improved the band definition of chromosomes; however, very little has changed with respect to improvements through automation. In this study, we compare chromosome analysis by traditional microscopy with semi-automatic karyotyping using robotic equipment from MetaSystems (Altlussheim, Germany). Analysis using MetaSystems was significantly quicker than using the microscope with an average reduction in analysis time of 26.5 minutes; for the average analyst, this equates to a reduction of 27 percent. Analysis checking times using MetaSystems showed even greater improvement with an average reduction in checking time of 11.4 minutes; for the average checker, this equates to a reduction of 48 percent. The MetaSystems semi-automatic karyotyping equipment offers increased throughput of cases for karyotype analysis while maintaining accuracy.", journal = "J Assoc Genet Technol", keywords = "Metafer MSearch Ikaros AutoCapt", number = "4", pages = "177--187", title = "An Evaluation of the Effectiveness of a Semi-automatic Metaphase Locating and On-screen Karyotyping System.", url = "http://www.agt-info.org/pdfs/AGT%20Journal%204th%20Qtr%2008%20final%20galley.pdf", volume = "34", year = "2008", }