@article{Fabarius2011,
author = "Alice Fabarius and Armin Leitner and Andreas Hochhaus and Martin C M{\"u}ller and Benjamin Hanfstein and Claudia Haferlach and Gudrun G{\"o}hring and Brigitte Schlegelberger and Martine Jotterand and Andreas Reiter and Susanne Jung-Munkwitz and Ulrike Proetel and Juliana Schwaab and Wolf-Karsten Hofmann and J{\"o}rg Schubert and Hermann Einsele and Anthony D Ho and Christiane Falge and Lothar Kanz and Andreas Neubauer and Michael Kneba and Frank Stegelmann and Michael Pfreundschuh and Cornelius F Waller and Karsten Spiekermann and Gabriela M Baerlocher and Michael Lauseker and Markus Pfirrmann and Joerg Hasford and Susanne Saussele and R{\"u}diger Hehlmann and f{\"u}r Klinische Krebsforschung (SAKK), Schweizerische Arbeitsg and the German CML Study Group,",
abstract = "The prognostic relevance of additional cytogenetic findings at diagnosis
	of chronic myeloid leukemia (CML) is unclear. The impact of additional
	cytogenetic findings at diagnosis on time to complete cytogenetic
	(CCR) and major molecular remission (MMR) and progression-free (PFS)
	and overall survival (OS) was analyzed using data from 1151 Philadelphia
	chromosome-positive (Ph(+)) CML patients randomized to the German
	CML Study IV. At diagnosis, 1003 of 1151 patients (87\%) had standard
	t(9;22)(q34;q11) only, 69 patients (6.0\%) had variant t(v;22), and
	79 (6.9\%) additional cytogenetic aberrations (ACAs). Of these, 38
	patients (3.3\%) lacked the Y chromosome (-Y) and 41 patients (3.6\%)
	had ACAs except -Y; 16 of these (1.4\%) were major route (second
	Philadelphia [Ph] chromosome, trisomy 8, isochromosome 17q, or trisomy
	19) and 25 minor route (all other) ACAs. After a median observation
	time of 5.3 years for patients with t(9;22), t(v;22), -Y, minor-
	and major-route ACAs, the 5-year PFS was 90\%, 81\%, 88\%, 96\%,
	and 50\%, and the 5-year OS was 92\%, 87\%, 91\%, 96\%, and 53\%,
	respectively. In patients with major-route ACAs, the times to CCR
	and MMR were longer and PFS and OS were shorter (P ",
journal = "Blood",
keywords = "XCyte mBAND Isis",
month = "Dec",
number = "26",
pages = "6760--6768",
title = "Impact of additional cytogenetic aberrations at diagnosis on prognosis	of CML: long-term observation of 1151 patients from the randomized	CML Study IV.",
url = "http://bloodjournal.hematologylibrary.org/content/118/26/6760.full",
volume = "118",
year = "2011",
}